Recent Products & Developments

Chelsea Technologies Grou (CTG) offers a comprehensive instrument development services from concept to manufacture delivering innovative products to clients on time and to budget. Let us help you get your product idea off the ground.

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Foot and MouthFoot and Mouth Detection - Stratophase, University of Cambridge, Bristol Industrial Research Associates

An optical sensor chip that started life as a way of fighting bio-terrorism is now being used in a test for foot-and-mouth disease. Chelsea Technologies Group in collaboration with Stratophase, University of Cambridge, Bristol Industrial & Research Associates have been involved in a £1m project to develop a test to identify foot-and-mouth disease on the spot. It is more sensitive and accurate than existing field-deployable systems, and much faster than laboratory-based techniques.  Chelsea has over 45 year’s experience in the design and manufacture of bio-medical instrumentation and were delighted to provide system integration and product design to this cutting edge project.

 

MicroArrayOn-Site Rapid Diagnostics Screening - Microtest Matrices Ltd & The Health Inspection Agency

Chelsea Technologies Group has developed an ‘on-site rapid diagnostics screening system’ to detect and identify micro-organisms following a terrorist attack.  Over recent years Chelsa has developed a novel, low-cost, optical system for reading low-density protein microarrays, work that was done in partnership with Microtest Matrices Ltd, (a spin out from Imperial College). With Home Office sponsorship, this advance has enabled the CTG, MtM and The Health Inspection Agency  to develop a fully automated portable microarray processing platform for on-site diagnosis, a step which had hitherto been inhibited by the sophistication and expense of the optical imaging techniques available for reading high density DNA arrays.

 

MicroArrayRapid Point of Care for AC1 Quotient Diagnostics Ltd

A key part of ensuring that diabetics live long and healthy lives is to havve close control of their condition. Quotient Diagnostics developed a technology that is revolutionizing how diabetes is monitored and managed. Working with Chelsea Technologies Group they have produced an instrument to provide an on-the-spot reading of glycated haemoglobin, a vital indicator of a diabetic's condition, known as the A1C test. Chelsea worked with Quotient to supply them with five rapid  prototypes, the system is now in full production.

Osmatech Molecular DiagnosticsBringing Molecular Diagnostics to Near Patient Testing - Osmetech Molecular Diagnostics

Chelsea designed a innovative, rapid and flexible PCR platform for Osmetech Molecular Diagnostics,  making genetic tests a reality in the near point of care market. The Opti Gene developed for Osmetech uses proven, well-accepted PCR technology - random access and fully independent thermal cycling in every tube. It permits 12 independent PCR cycles simultaneously; well suited to PCR assay panel testing. It has a rapid thermal cycling time and intuitive touch-screen display and analysis software. Enhanced reliability is gained by having a homogeneous, closed tube format to reduce potential contamination.

GeneDriverFluorescence based, 24 channel, quantitative PCR system - Molecular Sensing Ltd

Molecular Sensing approached us  to develop a fluorescence based, 24 channel, quantitative PCR system with each channel capable of running an independent thermal profile. A custom moulded sample tube and disposable test cartridge were first designed. An innovative and highly efficiency optical system was devised, which had sub-nanomolar sensitivity in 20mL of sample with a photomultiplier detector operating at relatively low gain, while at the same time being insensitive to component alignment in assembly. A heater circuit was developed to control each of the 24 four channels independently while also providing the rapid cycling response required by the application. The complete system was developed within a year.

Microgen Bioproducts - PulsifierPulsifier - Microgen Bioproducts Ltd

The Pulsifier uses a reciprocating beater-bar to send shock waves through a food sample to drive microbes into solution to aid microbial analysis. Food suspensions produced in this way are generally much clearer than can be achieved using traditional blenders and require less downstream processing. Microgen Bioproducts Ltd asked us to production engineer their prototype to meet a competitive price target, reduce operating noise, provide an attractive styling for the product and incorporate microprocessor control. Acoustic analysis indicated that a significant reduction in operating noise could be achieved by sealing the sample within the unit while processing.

First Rapid Point of Care Test for HbA1CHaemaQuant, First Rapid Point of Care Test for HbA1C - Provalis plc

The Chelsea design team worked closely with Provalis’ biochemists to realise their vision of a portable, low cost assay platform. HaemaQuant™ has laboratory level photometric performance but with the convenience and clinical advantages of a point-of-care test. It has been designed for low cost manufacture with signal to noise characteristics in the region of 10,000:1.  Chelsea also designed the novel disposable cartridge that provides both the assay platform, for the complex chemical/immunochemical reactions, and provision for photometric analysis of up to 4 liquid fractions.

AutoTitratorAuto-Titrator - Malvern Instruments

Malvern Instruments, the world-leading manufacturer of particle size analysis instrumentation incorporated a Chelsea designed auto-titrator into their Zetasizer range of products. This new compact fluid preparation and analysis system was designed to allow precise volumes of up to 3 reagents to be dispensed into a disposable sample container under the control of the Zetasizer system, thus providing an automatic titration facility. This system is available from Chelsea as an auto-titrator or can be configured for other precise liquid processing applications, where a close link to a specific measurement system is required.

DrewLow Cost UV HPLC fluorometer - Drew Scientific

Drew Scientific asked Chelsea to design a compact, low cost, UV fluorometer that could be incorporated into their DS30 Hcy liquid chromatography system being developed for the routine monitoring of homocysteine, a marker for coronary heart disease. We quickly established the demanding sensitivity requirements and through optimisation of the optical design and detector electronics were able to improve the sensitivity to five times better than the requirement. The time taken from initial client contact to delivery of the first production units was less than 7 months. A recent redesign replacing the flash source with an LED has enabled a dramatic reduction in production costs to be made with no loss in performance.

InstaQuantInstaQuant: Hand Held Reader for Immunostrip Test Devices - Provalis Diagnostics

Provalis Diagnostics had already developed a visual ‘one-step’ test device for the monitoring of osteoporosis. The challenge Provalis set us was to develop a simple, lost-cost, hand-held photometer that could provide a more objective quantitative result. Using rapid prototyping techniques a fully functional prototype, virtually identical in appearance to the final product, was produced within 4 months and the final instrument was ready for volume production in less than 10 months. We have investigated & assessed a range of options for analysing strip tests and this 'know how' is available for future developments.

DarasDARAS®: First Fully Automated DNA Analysis System - Tepnel Life Sciences PLC

The DARAS® System provides a controlled environment for the automation of routine molecular biology procedures on solid particles retained within a disposable reaction column.  Using a novel flow through fluid handling approach, the instrument combines robotic control of the reaction columns, precise temperature control and on-line photometry to facilitate sequence specific capture and detection of DNA, normally achieved using manual processes. Chelsea developed Tepnel's prototype system redesigning the complete system, encompassing the mechanical, electrical, optical & industrial design as well as the user interface and embedded software.

ShakerIncubator Microtitre Plate Shaker Incubator - Amersham International PLC  

The Shaker Incubator was originally developed by Chelsea to support Amersham International’s Amerlite range of diagnostics. The primary objective was to reduce assay incubation times and avoid the variability from non-uniform heating, edge and drying effects associated with forced warm air incubation techniques. Over 3500 units were produced.

FluorescentCapillaryFillDeviceTechnologyFluorescent Capillary Fill Device Technology - Quantimmune Systems

Chelsea worked with Quantimune System to produce a Fluorescent Capillary Fill Device which incorporated a high sensitivity PMT based fluorometer, novel optical design, solid state source with telecentric optics, precision opto-mechanical interface and integrated disposable test device.

PhotometerPhotometer - European Diagnostics Group Ltd 

The portable lab based clinical analyser designed for European Diagnostics Group Ltd has on-board incubation, tube/microtitre well based reader, integrated assay interpolation and has been designed for low cost manufacture.

 

......and these's more!

AutoPrep12: DNA Preparation Station - Cambridge Molecular Technologies Ltd

Hand Held Alcohol Meter - SensAlyse Ltd

FT500 UV Fourier Transform Spectrometer - Chelsea Technologies Group

CI4000 Protein Sequencer - Chelsea Technologies Group

Design & Mass Production of Electronic Test Plate - Chelsea Technologies Group